Better models of translational biological systems are continually being sought by the biomedical research community. In comparison to animal models or immortalized cell models, human primary cells demonstrate increased physiological relevance in terms of response, efficacy, and toxicity (Hynds, 2013). In particular, reliable and accurate models of lung function are highly sought after to model […]
Liver disease is more common than you might think. Liver diseases pose a significant and rapidly growing problem for national health care systems throughout the world. Globally, 50 million adults will be affected with chronic liver disease — which includes scarring of the liver, inflammation from infectious and non-infectious causes — according to estimates from the World Gastroenterology […]
Primary human intestinal cells are ideal to study intestinal physiology, model the pathophysiology of gastrointestinal disease, and evaluate the efﬁcacy or toxicity of orally administered drugs during preclinical development.
Because nephrotoxicity may affect one or more kidney cell types, the identification and evaluation of potential nephrotoxic effects is a challenging endeavor for pharmaceutical scientists