Upon receipt, immediately transfer each cryovial into the vapor phase of a liquid nitrogen storage dewar. Cryopreserved human hepatocytes are viable for at least 2 years when stored under these conditions.
Cryopreserved, Plateable Primary Human Hepatocytes are isolated from whole human livers that are not suitable for liver transplantation. The cell composition consists of a homogenous population of hepatocytes which are characterized by viability, morphology, plating efficiency and various functional testing including multiple CYP450 basal and induction levels including CYP3A4, CYP2D6, CYP2C9, CYP1A2, and CYP2B6. In addition, Novabiosis primary human hepatocytes will undergo an ECOD study for 7-HCG and 7-HCS formation, and finally each lot will be tested for its ability to maintain function for a minimum period of 5 days and will be reported on the quality control report delivered with each vial.
Normal Human Hepatocyte Characterized Plateable are for research use only and not approved for human or animal use, nor for in vivo diagnostic testing.
Novabiosis Plateable Primary Human Hepatocytes can be used for induction, toxicity, drug metabolism, drug screening, drug transporter activity, drug-drug interaction, among other uses.